Transancestral mapping and genetic load in systemic lupus erythematosus

Carl D. Langefeld (), Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney () and Timothy J. Vyse ()
Additional contact information
Carl D. Langefeld: Center for Public Health Genomics, Wake Forest School of Medicine
Hannah C. Ainsworth: Center for Public Health Genomics, Wake Forest School of Medicine
Deborah S. Cunninghame Graham: Infection and Inflammatory Diseases, King’s College London, Guy’s Hospital
Jennifer A. Kelly: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Mary E. Comeau: Center for Public Health Genomics, Wake Forest School of Medicine
Miranda C. Marion: Center for Public Health Genomics, Wake Forest School of Medicine
Timothy D. Howard: Center for Public Health Genomics, Wake Forest School of Medicine
Paula S. Ramos: Medical University of South Carolina
Jennifer A. Croker: UAB School of Medicine
David L. Morris: Infection and Inflammatory Diseases, King’s College London, Guy’s Hospital
Johanna K. Sandling: Molecular Medicine and Science for Life Laboratory, Uppsala University
Jonas Carlsson Almlöf: Molecular Medicine and Science for Life Laboratory, Uppsala University
Eduardo M. Acevedo-Vásquez: Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San Marcos
Graciela S. Alarcón: UAB School of Medicine
Alejandra M. Babini: Hospital Italiano de Córdoba
Vicente Baca: Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
Anders A. Bengtsson: Rheumatology, Lund University
Guillermo A. Berbotto: Hospital Eva Perón
Marc Bijl: Martini Hospital
Elizabeth E. Brown: UAB School of Medicine
Hermine I. Brunner: Cincinnati Children’s Hospital Medical Center and the University of Cincinnati
Mario H. Cardiel: Centro de Investigación Clínica de Morelia
Luis Catoggio: Hospital Italiano de Buenos Aires
Ricard Cervera: Hospital Clínic, University of Barcelona
Jorge M. Cucho-Venegas: Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San Marcos
Solbritt Rantapää Dahlqvist: Umeå University
Sandra D’Alfonso: University of Eastern Piedmont
Berta Martins Da Silva: Unidade Multidisciplinar em Investigação Biomédica/Instituto de Ciências Biomédicas de Abel Salazar—Universidade do Porto
Iñigo de la Rúa Figueroa: Hospital Universitario de Gran Canaria Dr Negrín
Andrea Doria: University of Padua
Jeffrey C. Edberg: UAB School of Medicine
Emőke Endreffy: Albert Szent-Györgyi Medical Center, Faculty of Medicine, University of Szeged
Jorge A. Esquivel-Valerio: Hospital Universitario ‘Dr José Eleuterio González’ Universidad Autonoma de Nuevo León
Paul R. Fortin: CHU de Québec Université Laval
Barry I. Freedman: Center for Public Health Genomics, Wake Forest School of Medicine
Johan Frostegård: Institute of Environmental Medicine, Unit of Immunology and Chronic diseases, Karolinska Institutet
Mercedes A. García: Hospital Interzonal General de Agudos General San Martín
Ignacio García de la Torre: University of Guadalajara
Gary S. Gilkeson: Medical University of South Carolina
Dafna D. Gladman: Centre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western Hospital
Iva Gunnarsson: Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital
Joel M. Guthridge: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Jennifer L. Huggins: Cincinnati Children’s Hospital Medical Center and the University of Cincinnati
Judith A. James: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Cees G. M. Kallenberg: Department of Rheumatology and Clinical Immunology,University Medical Center Groningen,University of Groningen
Diane L. Kamen: Medical University of South Carolina
David R. Karp: University of Texas SouthWestern Medical Center
Kenneth M. Kaufman: Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
Leah C. Kottyan: Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
László Kovács: Albert Szent-Györgyi Medical Centre, University of Szeged
Helle Laustrup: Odense University Hospital
Bernard R. Lauwerys: Rheumatology, Cliniques Universitaires Saint-Luc & Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain
Quan-Zhen Li: University of Texas SouthWestern Medical Center
Marco A. Maradiaga-Ceceña: Hospital General de Culiacán
Javier Martín: Instituto de Parasitología y Biomedicina López Neyra, CSIC
Joseph M. McCune: University of Michigan Medical Center
David R. McWilliams: Center for Public Health Genomics, Wake Forest School of Medicine
Joan T. Merrill: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Pedro Miranda: Centro de Estudios Reumatológicos, Santiago de Chile
José F. Moctezuma: Hospital General de México
Swapan K. Nath: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Timothy B. Niewold: Mayo Clinic
Lorena Orozco: Instituto Nacional de Medicina Genómica (INMEGEN)
Norberto Ortego-Centeno: Unidad de Enfermedades Autoimmunes Sistémicas, UGC Medicina Interna, Hospital Universitario San Cecilio
Michelle Petri: Johns Hopkins University School of Medicine
Christian A. Pineau: McGill University
Bernardo A. Pons-Estel: Sanatorio Parque
Janet Pope: University of Western Ontario
Prithvi Raj: University of Texas SouthWestern Medical Center
Rosalind Ramsey-Goldman: Northwestern University Feinberg School of Medicine
John D. Reveille: The University of Texas Health Science Center at Houston (UTHealth) Medical School
Laurie P. Russell: Center for Public Health Genomics, Wake Forest School of Medicine
José M. Sabio: Hospital Universitario Virgen de las Nieves
Carlos A. Aguilar-Salinas: Instituto Nacional de Ciencias Médicas y Nutrición
Hugo R. Scherbarth: Unidad Reumatología y Enfermedades Autoinmunes H.I.G.A. Dr Alende Mar del Plata
Raffaella Scorza: Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca'Granda Ospedale Ma Repiore Policlinico and University of Milan
Michael F. Seldin: UC Davis School of Medicine
Christopher Sjöwall: Linköping University
Elisabet Svenungsson: Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital
Susan D. Thompson: Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
Sergio M. A. Toloza: Ministry of Health, San Fernando del Valle de Catamarca
Lennart Truedsson: Section of Microbiology, Immunology and Glycobiology, Lund University
Teresa Tusié-Luna: Unidad de Biología Molecular y Medicina Genómica Instituto de Investigaciones Biomédicas/UNAM Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Carlos Vasconcelos: Hospital Santo Antonio, Universidade do Porto
Luis M. Vilá: University of Puerto Rico School of Medicine
Daniel J. Wallace: Cedars Sinai Medical Center
Michael H. Weisman: Cedars Sinai Medical Center
Joan E. Wither: Centre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western Hospital
Tushar Bhangale: Human Genetics, Genentech Inc, South San Francisco
Jorge R. Oksenberg: University of California at San Francisco
John D. Rioux: Université de Montréal and the Montreal Heart Institute
Peter K. Gregersen: Center for Genomics & Human Genetics, The Feinstein Institute for Medical Research
Ann-Christine Syvänen: Molecular Medicine and Science for Life Laboratory, Uppsala University
Lars Rönnblom: Rheumatology, Uppsala University
Lindsey A. Criswell: Rosalind Russell/Ephraim P Engleman Rheumatology Research Center, UCSF School of Medicine
Chaim O. Jacob: Keck School of Medicine of USC
Kathy L. Sivils: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Betty P. Tsao: Medical University of South Carolina
Laura E. Schanberg: Duke University
Timothy W. Behrens: Human Genetics, Genentech Inc, South San Francisco
Earl D. Silverman: The Hospital for Sick Children, Hospital for Sick Children Research Institute and University of Toronto
Marta E. Alarcón-Riquelme: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Robert P. Kimberly: UAB School of Medicine
John B. Harley: Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center
Edward K. Wakeland: University of Texas SouthWestern Medical Center
Robert R. Graham: Human Genetics, Genentech Inc, South San Francisco
Patrick M. Gaffney: Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation
Timothy J. Vyse: Infection and Inflammatory Diseases, King’s College London, Guy’s Hospital

Nature Communications, 2017, vol. 8, issue 1, 1-18

Abstract: Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P

Date: 2017
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DOI: 10.1038/ncomms16021

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