Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

Zhipeng Xu, Lei Xu, Wei Li, Xin Jin, Xian Song, Xiaojun Chen (), Jifeng Zhu, Sha Zhou, Yong Li, Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen and Chuan Su ()
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Zhipeng Xu: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Lei Xu: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Wei Li: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Xin Jin: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Xian Song: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Xiaojun Chen: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Jifeng Zhu: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Sha Zhou: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Yong Li: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Weiwei Zhang: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Xiaoxiao Dong: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Xiaowei Yang: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Feng Liu: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University
Hui Bai: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University
Qi Chen: Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University
Chuan Su: Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifies a role for SR-A as an innate PRR in regulating adaptive immune responses.

Date: 2017
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DOI: 10.1038/ncomms16035

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