Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Sungjun Park, Seungwon Lee, Choong-Gu Lee, Guk Yeol Park, Hyebeen Hong, Jeon-Soo Lee, Young Min Kim, Sung Bae Lee, Daehee Hwang, Youn Soo Choi, John D. Fryer, Sin-Hyeog Im (), Seung-Woo Lee () and Yoontae Lee ()
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Sungjun Park: Pohang University of Science and Technology
Seungwon Lee: Pohang University of Science and Technology
Choong-Gu Lee: Academy of Immunology and Microbiology, Institute for Basic Science
Guk Yeol Park: Pohang University of Science and Technology
Hyebeen Hong: Pohang University of Science and Technology
Jeon-Soo Lee: Pohang University of Science and Technology
Young Min Kim: Pohang University of Science and Technology
Sung Bae Lee: Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Daehee Hwang: Center for Plant Aging Research, Institute for Basic Science, DGIST
Youn Soo Choi: Seoul National University College of Medicine
John D. Fryer: Mayo Clinic
Sin-Hyeog Im: Pohang University of Science and Technology
Seung-Woo Lee: Pohang University of Science and Technology
Yoontae Lee: Pohang University of Science and Technology

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (TFH) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity. CIC deficiency induces excessive development of TFH cells and GC responses in a T-cell-intrinsic manner. ETV5 expression is derepressed in Cic null TFH cells and knockdown of Etv5 suppresses the enhanced TFH cell differentiation in Cic-deficient CD4+ T cells, suggesting that Etv5 is a critical CIC target gene in TFH cell differentiation. Furthermore, we identify Maf as a downstream target of the CIC–ETV5 axis in this process. These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates TFH cell development and autoimmunity.

Date: 2017
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DOI: 10.1038/ncomms16037

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