Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Michel Enamorado, Salvador Iborra, Elena Priego, Francisco J. Cueto, Juan A. Quintana, Sarai Martínez-Cano, Ernesto Mejías-Pérez, Mariano Esteban, Ignacio Melero, Andrés Hidalgo and David Sancho ()
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Michel Enamorado: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Salvador Iborra: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Elena Priego: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Francisco J. Cueto: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Juan A. Quintana: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Sarai Martínez-Cano: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Ernesto Mejías-Pérez: Centro Nacional de Biotecnología
Mariano Esteban: Centro Nacional de Biotecnología
Ignacio Melero: Center for Applied Medical Research (CIMA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
Andrés Hidalgo: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
David Sancho: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8+ T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8+ T cells subsets needed for optimal tumour vaccination and immunotherapy.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16073

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DOI: 10.1038/ncomms16073

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