Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters

Xin-Jun Zhang, Zhizhong Li, Zhi Han, Khadeejah T. Sultan, Kun Huang and Song-Hai Shi ()
Additional contact information
Xin-Jun Zhang: Developmental Biology Program, Memorial Sloan Kettering Cancer Center
Zhizhong Li: Developmental Biology Program, Memorial Sloan Kettering Cancer Center
Zhi Han: The Ohio State University
Khadeejah T. Sultan: Developmental Biology Program, Memorial Sloan Kettering Cancer Center
Kun Huang: The Ohio State University
Song-Hai Shi: Developmental Biology Program, Memorial Sloan Kettering Cancer Center

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other. This lineage-related electrical coupling forms predominantly between the same interneuron subtype over an extended postnatal period and across a range of distances, and promotes action potential generation and synchronous firing. Interestingly, this selective electrical coupling relates to a coordinated inhibitory chemical synapse formation between sparsely labelled interneurons in clusters and the same nearby excitatory neurons. These results suggest a link between the lineage relationship of neocortical interneurons and their precise functional organization.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms16091 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16091

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms16091

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().