Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

M. Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M. Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L. Koller, Zoltán Kutalik, Jian’an Luan, Ida Malkin, Janina S. Ried, Albert V. Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J. Baier, Inês Barroso, David A. Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B. Borecki, Aron S. Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A. Cauley, Peggy M. Cawthon, Henna Cederberg, Zhao Chen, Nam H. Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R. Cummings, Philip L. Jager, Ilja Demuth, Rosalie A. M. Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W. Enneman, Mike Erdos, Johan G. Eriksson, Joel Eriksson, Karol Estrada, Daniel S. Evans, Mary F. Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L. Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L. Hanson, Caroline Hayward, Albert Hofman, Eric P. Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J. Hubal, Alan Hubbard, Kim M. Huffman, Lise B. Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M. Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O. Kilpeläinen, Norman Klopp, Jacqueline S. L. Kloth, Heikki A. Koistinen, William E. Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L. Langdahl, Lenore J. Launer, Jong-Young Lee, Markus M. Lerch, Joshua R. Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N. Luben, William Maixner, Fiona E. McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D. Mitchell, Andrew P. Morris, Leif Mosekilde, Anne Newman, Carrie M. Nielson, Jeffrey R. O’Connell, Ben A. Oostra, Eric S. Orwoll, Aarno Palotie, Stephen C. J. Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L. Prince, Katri Räikkönen, Stuart H. Ralston, Samuli Ripatti, John A. Robbins, Jerome I. Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E. Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A. Streeten, Unnur Styrkarsdottir, Karin M. A. Swart, Sian-Tsung Tan, Mark A. Tarnopolsky, Patricia Thompson, Cynthia A. Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J. Tranah, Jaakko Tuomilehto, Natasja M. Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N. Weedon, Ryan Welch, H.-Erich Wichmann, Elisabeth Widen, Frances M. K. Williams, James F. Wilson, Nicole C. Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C. Chambers, Angela Döring, Cornelia M. Duijn, Michael J. Econs, Vilmundur Gudnason, Jaspal S. Kooner, Bruce M. Psaty, Timothy D. Spector, Kari Stefansson, Fernando Rivadeneira, André G. Uitterlinden, Nicholas J. Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J. F. Loos, David Karasik, Tamara B. Harris, Claes Ohlsson and Douglas P. Kiel ()
Additional contact information
M. Carola Zillikens: Erasmus MC
Serkalem Demissie: Boston University School of Public Health
Yi-Hsiang Hsu: Hebrew SeniorLife, Institute for Aging Research
Laura M. Yerges-Armstrong: University of Maryland School of Medicine
Wen-Chi Chou: Hebrew SeniorLife, Institute for Aging Research
Lisette Stolk: Erasmus MC
Gregory Livshits: Tel Aviv University
Linda Broer: Erasmus MC
Toby Johnson: University of Lausanne
Daniel L. Koller: Indiana University School of Medicine
Zoltán Kutalik: University of Lausanne
Jian’an Luan: Cambridge Biomedical Campus
Ida Malkin: Tel Aviv University
Janina S. Ried: Helmholtz Zentrum München – German Research Center for Environmental Health
Albert V. Smith: Icelandic Heart Association
Gudmar Thorleifsson: deCODE Genetics
Liesbeth Vandenput: University of Gothenburg
Jing Hua Zhao: Cambridge Biomedical Campus
Weihua Zhang: Imperial College
Ali Aghdassi: University of Greifswald
Kristina Åkesson: Lund University
Najaf Amin: Erasmus MC
Leslie J. Baier: National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Inês Barroso: Wellcome Trust Genome Campus
David A. Bennett: Rush University Medical Center
Lars Bertram: University of Lübeck
Rainer Biffar: University of Greifswald
Murielle Bochud: University Institute for Social and Preventive Medicine
Michael Boehnke: University of Michigan
Ingrid B. Borecki: Washington University School of Medicine
Aron S. Buchman: Rush University Medical Center
Liisa Byberg: Uppsala University
Harry Campbell: University of Edinburgh
Natalia Campos Obanda: Erasmus MC
Jane A. Cauley: University of Pittsburgh
Peggy M. Cawthon: California Pacific Medical Center Research Institute
Henna Cederberg: University of Eastern Finland and Kuopio University Hospital
Zhao Chen: University of Arizona
Nam H. Cho: Ajou University School of Medicine
Hyung Jin Choi: Seoul National University College of Medicine
Melina Claussnitzer: Hebrew SeniorLife, Institute for Aging Research
Francis Collins: National Human Genome Research Institute
Steven R. Cummings: California Pacific Medical Center Research Institute
Philip L. Jager: Harvard Medical School
Ilja Demuth: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Rosalie A. M. Dhonukshe-Rutten: Wageningen University, PO Box 17
Luda Diatchenko: McGill University
Gudny Eiriksdottir: Icelandic Heart Association
Anke W. Enneman: Erasmus MC
Mike Erdos: National Human Genome Research Institute
Johan G. Eriksson: University of Helsinki
Joel Eriksson: University of Gothenburg
Karol Estrada: Erasmus MC
Daniel S. Evans: California Pacific Medical Center Research Institute
Mary F. Feitosa: Washington University School of Medicine
Mao Fu: University of Maryland School of Medicine
Melissa Garcia: National Institute for Aging
Christian Gieger: Helmholtz Zentrum München – German Research Center for Environmental Health
Thomas Girke: University of California
Nicole L. Glazer: Boston University School of Medicine and Public Health
Harald Grallert: Helmholtz Zentrum München – German Research Center for Environmental Health
Jagvir Grewal: Ealing Hospital NHS Trust
Bok-Ghee Han: Osong Health Technology Administration Complex
Robert L. Hanson: National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Caroline Hayward: University of Edinburgh
Albert Hofman: Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
Eric P. Hoffman: SUNY Binghamton
Georg Homuth: University of Greifswald
Wen-Chi Hsueh: National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Monica J. Hubal: George Washington University
Alan Hubbard: University of California
Kim M. Huffman: Duke University School of Medicine
Lise B. Husted: Aarhus University Hospital
Thomas Illig: Helmholtz Zentrum München - German Research Center for Environmental Health
Erik Ingelsson: Uppsala University
Till Ittermann: University of Greifswald
John-Olov Jansson: University of Gothenburg
Joanne M. Jordan: University of North Carolina at Chapel Hill
Antti Jula: National Institute for Health and Welfare
Magnus Karlsson: Lund University, Skåne University Hospital SUS
Kay-Tee Khaw: University of Cambridge
Tuomas O. Kilpeläinen: Cambridge Biomedical Campus
Norman Klopp: Helmholtz Zentrum München - German Research Center for Environmental Health
Jacqueline S. L. Kloth: Erasmus MC
Heikki A. Koistinen: University of Helsinki and Helsinki University Central Hospital
William E. Kraus: Duke University School of Medicine
Stephen Kritchevsky: Wake Forest School of Medicine
Teemu Kuulasmaa: University of Eastern Finland and Kuopio University Hospital
Johanna Kuusisto: University of Eastern Finland and Kuopio University Hospital
Markku Laakso: University of Eastern Finland and Kuopio University Hospital
Jari Lahti: University of Helsinki
Thomas Lang: University of California San Francisco
Bente L. Langdahl: Aarhus University Hospital
Lenore J. Launer: National Institute for Aging
Jong-Young Lee: Osong Health Technology Administration Complex
Markus M. Lerch: University of Greifswald
Joshua R. Lewis: University of Western Australia
Lars Lind: Uppsala University
Cecilia Lindgren: Oxford University
Yongmei Liu: Wake Forest School of Medicine
Tian Liu: Max Planck Institute for Molecular Genetics
Youfang Liu: University of North Carolina at Chapel Hill
Östen Ljunggren: Uppsala University
Mattias Lorentzon: University of Gothenburg
Robert N. Luben: University of Cambridge
William Maixner: University of North Carolina at Chapel Hill
Fiona E. McGuigan: Lund University
Carolina Medina-Gomez: Erasmus MC
Thomas Meitinger: Technische Universität München
Håkan Melhus: Uppsala University
Dan Mellström: University of Gothenburg
Simon Melov: Buck Institute for Research on Aging
Karl Michaëlsson: Uppsala University
Braxton D. Mitchell: University of Maryland School of Medicine
Andrew P. Morris: Oxford University
Leif Mosekilde: Aarhus University Hospital
Anne Newman: University of Pittsburgh
Carrie M. Nielson: Oregon Health & Science University
Jeffrey R. O’Connell: University of Maryland School of Medicine
Ben A. Oostra: Erasmus MC
Eric S. Orwoll: Oregon Health & Science University
Aarno Palotie: University of Helsinki
Stephen C. J. Parker: University of Michigan
Munro Peacock: Indiana University School of Medicine
Markus Perola: National Institute for Health and Welfare
Annette Peters: Helmholtz Zentrum München – German Research Center for Environmental Health
Ozren Polasek: University of Split
Richard L. Prince: University of Western Australia
Katri Räikkönen: University of Helsinki
Stuart H. Ralston: Western General Hospital
Samuli Ripatti: University of Helsinki
John A. Robbins: University of California at Davis
Jerome I. Rotter: Harbor UCLA Medical Center
Igor Rudan: University of Edinburgh
Veikko Salomaa: National Institute for Health and Welfare
Suzanne Satterfield: University of Tennessee Health Science Center
Eric E. Schadt: Icahn School of Medicine at Mount Sinai
Sabine Schipf: University of Greifswald
Laura Scott: University of Michigan
Joban Sehmi: Ealing Hospital NHS Trust
Jian Shen: Oregon Health & Science University
Chan Soo Shin: Seoul National University College of Medicine
Gunnar Sigurdsson: University of Iceland
Shad Smith: Duke University Medical Center
Nicole Soranzo: Wellcome Trust Genome Campus
Alena Stančáková: University of Eastern Finland and Kuopio University Hospital
Elisabeth Steinhagen-Thiessen: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Elizabeth A. Streeten: University of Maryland School of Medicine
Unnur Styrkarsdottir: deCODE Genetics
Karin M. A. Swart: VU University Medical Center
Sian-Tsung Tan: Ealing Hospital NHS Trust
Mark A. Tarnopolsky: McMaster University Medical Center
Patricia Thompson: Stony Brook School of Medicine
Cynthia A. Thomson: University of Arizona
Unnur Thorsteinsdottir: University of Iceland
Emmi Tikkanen: National Institute for Health and Welfare
Gregory J. Tranah: California Pacific Medical Center Research Institute
Jaakko Tuomilehto: Vasa Central Hospital
Natasja M. Schoor: VU University Medical Center
Arjun Verma: Ealing Hospital NHS Trust
Peter Vollenweider: Centre Hospitalier Universitaire Vaudois (CHUV)
Henry Völzke: University of Greifswald
Jean Wactawski-Wende: University at Buffalo, State University of New York
Mark Walker: Newcastle University
Michael N. Weedon: University of Exeter Medical School
Ryan Welch: University of Michigan
H.-Erich Wichmann: Helmholtz Zentrum München – German Research Center for Environmental Health
Elisabeth Widen: University of Helsinki
Frances M. K. Williams: St Thomas’ Campus
James F. Wilson: University of Edinburgh
Nicole C. Wright: University of Alabama at Birmingham
Weijia Xie: University of Exeter Medical School
Lei Yu: Rush University Medical Center
Yanhua Zhou: Boston University School of Public Health
John C. Chambers: Imperial College
Angela Döring: Helmholtz Zentrum München – German Research Center for Environmental Health
Cornelia M. Duijn: Erasmus MC
Michael J. Econs: Indiana University School of Medicine
Vilmundur Gudnason: Icelandic Heart Association
Jaspal S. Kooner: Ealing Hospital NHS Trust
Bruce M. Psaty: University of Washington
Timothy D. Spector: St Thomas’ Campus
Kari Stefansson: University of Iceland
Fernando Rivadeneira: Erasmus MC
André G. Uitterlinden: Erasmus MC
Nicholas J. Wareham: Cambridge Biomedical Campus
Vicky Ossowski: National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Dawn Waterworth: Medical Genetics, GlaxoSmithKline
Ruth J. F. Loos: Cambridge Biomedical Campus
David Karasik: Hebrew SeniorLife, Institute for Aging Research
Tamara B. Harris: National Institute for Aging
Claes Ohlsson: University of Gothenburg
Douglas P. Kiel: Hebrew SeniorLife, Institute for Aging Research

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p

Date: 2017
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DOI: 10.1038/s41467-017-00031-7

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