Yeast Cip1 is activated by environmental stress to inhibit Cdk1–G1 cyclins via Mcm1 and Msn2/4

Ya-Lan Chang, Shun-Fu Tseng, Yu-Ching Huang, Zih-Jie Shen, Pang-Hung Hsu, Meng-Hsun Hsieh, Chia-Wei Yang, Silvia Tognetti, Berta Canal, Laia Subirana, Chien-Wei Wang, Hsiao-Tan Chen, Chi-Ying Lin, Francesc Posas and Shu-Chun Teng ()
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Ya-Lan Chang: National Taiwan University
Shun-Fu Tseng: National Taiwan University
Yu-Ching Huang: National Taiwan University
Zih-Jie Shen: National Taiwan University
Pang-Hung Hsu: National Taiwan Ocean University
Meng-Hsun Hsieh: National Taiwan University
Chia-Wei Yang: National Taiwan University
Silvia Tognetti: Universitat Pompeu Fabra
Berta Canal: Universitat Pompeu Fabra
Laia Subirana: Universitat Pompeu Fabra
Chien-Wei Wang: National Taiwan University
Hsiao-Tan Chen: National Taiwan University
Chi-Ying Lin: National Taiwan University
Francesc Posas: Universitat Pompeu Fabra
Shu-Chun Teng: National Taiwan University

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Upon environmental changes, proliferating cells delay cell cycle to prevent further damage accumulation. Yeast Cip1 is a Cdk1 and Cln2-associated protein. However, the function and regulation of Cip1 are still poorly understood. Here we report that Cip1 expression is co-regulated by the cell-cycle-mediated factor Mcm1 and the stress-mediated factors Msn2/4. Overexpression of Cip1 arrests cell cycle through inhibition of Cdk1–G1 cyclin complexes at G1 stage and the stress-activated protein kinase-dependent Cip1 T65, T69, and T73 phosphorylation may strengthen the Cip1and Cdk1–G1 cyclin interaction. Cip1 accumulation mainly targets Cdk1–Cln3 complex to prevent Whi5 phosphorylation and inhibit early G1 progression. Under osmotic stress, Cip1 expression triggers transient G1 delay which plays a functionally redundant role with another hyperosmolar activated CKI, Sic1. These findings indicate that Cip1 functions similarly to mammalian p21 as a stress-induced CDK inhibitor to decelerate cell cycle through G1 cyclins to cope with environmental stresses.

Date: 2017
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DOI: 10.1038/s41467-017-00080-y

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