Triggerable tough hydrogels for gastric resident dosage forms

Jinyao Liu, Yan Pang, Shiyi Zhang, Cody Cleveland, Xiaolei Yin, Lucas Booth, Jiaqi Lin, Young-Ah Lucy Lee, Hormoz Mazdiyasni, Sarah Saxton, Ameya R. Kirtane, Thomas von Erlach, Jaimie Rogner, Robert Langer () and Giovanni Traverso ()
Additional contact information
Jinyao Liu: Massachusetts Institute of Technology
Yan Pang: Massachusetts Institute of Technology
Shiyi Zhang: Massachusetts Institute of Technology
Cody Cleveland: Massachusetts Institute of Technology
Xiaolei Yin: Massachusetts Institute of Technology
Lucas Booth: Massachusetts Institute of Technology
Jiaqi Lin: Massachusetts Institute of Technology
Young-Ah Lucy Lee: Massachusetts Institute of Technology
Hormoz Mazdiyasni: Massachusetts Institute of Technology
Sarah Saxton: Massachusetts Institute of Technology
Ameya R. Kirtane: Massachusetts Institute of Technology
Thomas von Erlach: Massachusetts Institute of Technology
Jaimie Rogner: Massachusetts Institute of Technology
Robert Langer: Massachusetts Institute of Technology
Giovanni Traverso: Massachusetts Institute of Technology

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell to ensure prolonged gastric residence, have the mechanical integrity to withstand the forces associated with gastrointestinal motility, be triggerable to address any side effects, and be drug loadable and release drug over a prolonged period of time. Materials that have been primarily utilized for these applications have been largely restricted to thermoplastics and thermosets. Here we describe a novel set of materials, triggerable tough hydrogels, meeting all these requirement, supported by evaluation in a large animal model and ultimately demonstrate the potential of triggerable tough hydrogels to serve as prolonged gastric resident drug depots. Triggerable tough hydrogels may be applied in myriad of applications, including bariatric interventions, drug delivery, and tissue engineering.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-017-00144-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00144-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-00144-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().