Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S. Henzel, Sabine M. Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L. Pearson, Ildiko Racz, Birgit Rathkolb, Devon P. Ryan, Susanne Schröder, Irina Treise, Raffi Bekeredjian, Dirk H. Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis and Dan Ehninger ()
Additional contact information
Kan Xie: German Center for Neurodegenerative Diseases
Frauke Neff: German Research Center for Environmental Health
Astrid Markert: German Center for Neurodegenerative Diseases
Jan Rozman: German Research Center for Environmental Health
Juan Antonio Aguilar-Pimentel: German Research Center for Environmental Health
Oana Veronica Amarie: German Research Center for Environmental Health
Lore Becker: German Research Center for Environmental Health
Robert Brommage: German Research Center for Environmental Health
Lillian Garrett: German Research Center for Environmental Health
Kristin S. Henzel: German Center for Neurodegenerative Diseases
Sabine M. Hölter: German Research Center for Environmental Health
Dirk Janik: German Research Center for Environmental Health
Isabelle Lehmann: German Center for Neurodegenerative Diseases
Kristin Moreth: German Research Center for Environmental Health
Brandon L. Pearson: German Center for Neurodegenerative Diseases
Ildiko Racz: German Research Center for Environmental Health
Birgit Rathkolb: German Research Center for Environmental Health
Devon P. Ryan: German Center for Neurodegenerative Diseases
Susanne Schröder: German Center for Neurodegenerative Diseases
Irina Treise: German Research Center for Environmental Health
Raffi Bekeredjian: University of Heidelberg
Dirk H. Busch: Technische Universität München
Jochen Graw: German Research Center for Environmental Health
Gerhard Ehninger: University Hospital Carl Gustav Carus, Technical University Dresden
Martin Klingenspor: Technische Universität München
Thomas Klopstock: Ludwig-Maximilians-Universität München
Markus Ollert: Luxembourg Institute of Health
Michael Sandholzer: German Research Center for Environmental Health
Carsten Schmidt-Weber: Technische Universität München and Helmholtz Zentrum München
Marco Weiergräber: Federal Institute for Drugs and Medical Devices
Eckhard Wolf: Ludwig-Maximilians-Universität München
Wolfgang Wurst: German Research Center for Environmental Health
Andreas Zimmer: University of Bonn
Valerie Gailus-Durner: German Research Center for Environmental Health
Helmut Fuchs: German Research Center for Environmental Health
Martin Hrabě de Angelis: German Research Center for Environmental Health
Dan Ehninger: German Center for Neurodegenerative Diseases

Nature Communications, 2017, vol. 8, issue 1, 1-19

Abstract: Abstract Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00178-3

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DOI: 10.1038/s41467-017-00178-3

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