HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Syed Ahsan Raza, Anne Albrecht, Gürsel Çalışkan, Bettina Müller, Yunus Emre Demiray, Susann Ludewig, Susanne Meis, Nicolai Faber, Roland Hartig, Burkhart Schraven, Volkmar Lessmann, Herbert Schwegler and Oliver Stork ()
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Syed Ahsan Raza: Otto-von-Guericke University
Anne Albrecht: Otto-von-Guericke University
Gürsel Çalışkan: Otto-von-Guericke University
Bettina Müller: Otto-von-Guericke University
Yunus Emre Demiray: Otto-von-Guericke University
Susann Ludewig: Otto-von-Guericke University
Susanne Meis: Otto-von-Guericke University
Nicolai Faber: Otto-von-Guericke University
Roland Hartig: Otto-von-Guericke University
Burkhart Schraven: Otto-von-Guericke University
Volkmar Lessmann: Otto-von-Guericke University
Herbert Schwegler: Otto-von-Guericke University
Oliver Stork: Otto-von-Guericke University

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Abstract Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00205-3

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DOI: 10.1038/s41467-017-00205-3

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