The non-coding RNA landscape of human hematopoiesis and leukemia

Adrian Schwarzer, Stephan Emmrich, Franziska Schmidt, Dominik Beck, Michelle Ng, Christina Reimer, Felix Ferdinand Adams, Sarah Grasedieck, Damian Witte, Sebastian Käbler, Jason W. H. Wong, Anushi Shah, Yizhou Huang, Razan Jammal, Aliaksandra Maroz, Mojca Jongen-Lavrencic, Axel Schambach, Florian Kuchenbauer, John E. Pimanda, Dirk Reinhardt, Dirk Heckl and Jan-Henning Klusmann ()
Additional contact information
Adrian Schwarzer: Hannover Medical School
Stephan Emmrich: Hannover Medical School
Franziska Schmidt: Hannover Medical School
Dominik Beck: UNSW Australia
Michelle Ng: Hannover Medical School
Christina Reimer: Hannover Medical School
Felix Ferdinand Adams: Hannover Medical School
Sarah Grasedieck: University Hospital of Ulm
Damian Witte: Hannover Medical School
Sebastian Käbler: Hannover Medical School
Jason W. H. Wong: UNSW Australia
Anushi Shah: UNSW Australia
Yizhou Huang: UNSW Australia
Razan Jammal: Hannover Medical School
Aliaksandra Maroz: Hannover Medical School
Mojca Jongen-Lavrencic: Erasmus University Medical Center
Axel Schambach: Hannover Medical School
Florian Kuchenbauer: University Hospital of Ulm
John E. Pimanda: UNSW Australia
Dirk Reinhardt: University Hospital Essen
Dirk Heckl: Hannover Medical School
Jan-Henning Klusmann: Hannover Medical School

Nature Communications, 2017, vol. 8, issue 1, 1-17

Abstract: Abstract Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of the human hematopoietic system. Based on highly specific non-coding RNA expression portraits per blood cell population, we identify unique fingerprint non-coding RNAs—such as LINC00173 in granulocytes—and assign these to critical regulatory circuits involved in blood homeostasis. Following the incorporation of acute myeloid leukemia samples into the landscape, we further uncover prognostically relevant non-coding RNA stem cell signatures shared between acute myeloid leukemia blasts and healthy hematopoietic stem cells. Our findings highlight the importance of the non-coding transcriptome in the formation and maintenance of the human blood hierarchy.

Date: 2017
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DOI: 10.1038/s41467-017-00212-4

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