Plasmonic silver nanoshells for drug and metabolite detection

Lin Huang, Jingjing Wan, Xiang Wei, Yu Liu, Jingyi Huang, Xuming Sun, Ru Zhang, Deepanjali D. Gurav, Vadanasundari Vedarethinam, Yan Li, Ruoping Chen () and Kun Qian ()
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Lin Huang: Shanghai Jiao Tong University
Jingjing Wan: Shanghai University
Xiang Wei: Shanghai Jiao Tong University
Yu Liu: Shanghai Jiao Tong University
Jingyi Huang: Shanghai Jiao Tong University
Xuming Sun: Shanghai Jiao Tong University
Ru Zhang: Shanghai Jiao Tong University
Deepanjali D. Gurav: Shanghai Jiao Tong University
Vadanasundari Vedarethinam: Shanghai Jiao Tong University
Yan Li: Chinese Academy of Sciences
Ruoping Chen: Shanghai Jiao Tong University
Kun Qian: Shanghai Jiao Tong University

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO2@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics.

Date: 2017
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DOI: 10.1038/s41467-017-00220-4

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