CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

Allah Nawaz, Aminuddin Aminuddin, Tomonobu Kado, Akiko Takikawa, Seiji Yamamoto, Koichi Tsuneyama, Yoshiko Igarashi, Masashi Ikutani, Yasuhiro Nishida, Yoshinori Nagai, Kiyoshi Takatsu, Johji Imura, Masakiyo Sasahara, Yukiko Okazaki, Kohjiro Ueki, Tadashi Okamura, Kumpei Tokuyama, Akira Ando, Michihiro Matsumoto, Hisashi Mori, Takashi Nakagawa, Norihiko Kobayashi, Kumiko Saeki, Isao Usui, Shiho Fujisaka () and Kazuyuki Tobe ()
Additional contact information
Allah Nawaz: University of Toyama
Aminuddin Aminuddin: University of Toyama
Tomonobu Kado: University of Toyama
Akiko Takikawa: University of Toyama
Seiji Yamamoto: University of Toyama
Koichi Tsuneyama: University of Toyama
Yoshiko Igarashi: University of Toyama
Masashi Ikutani: National Center for Global Health and Medicine
Yasuhiro Nishida: University of Toyama
Yoshinori Nagai: University of Toyama
Kiyoshi Takatsu: University of Toyama
Johji Imura: University of Toyama
Masakiyo Sasahara: University of Toyama
Yukiko Okazaki: The University of Tokyo
Kohjiro Ueki: The University of Tokyo
Tadashi Okamura: National Center for Global Health and Medicine
Kumpei Tokuyama: University of Tsukuba
Akira Ando: University of Tsukuba
Michihiro Matsumoto: National Center for Global Health and Medicine
Hisashi Mori: University of Toyama
Takashi Nakagawa: University of Toyama
Norihiko Kobayashi: National Center for Global Health and Medicine
Kumiko Saeki: National Center for Global Health and Medicine
Isao Usui: University of Toyama
Shiho Fujisaka: University of Toyama
Kazuyuki Tobe: University of Toyama

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like macrophages in adipose tissue regulate systemic glucose homeostasis by inhibiting adipocyte progenitor proliferation via the CD206/TGFβ signaling pathway. We show that adipose tissue CD206+ cells are primarily M2-like macrophages, and ablation of CD206+ M2-like macrophages improves systemic insulin sensitivity, which was associated with an increased number of smaller adipocytes. Mice genetically engineered to have reduced numbers of CD206+ M2-like macrophages show a down-regulation of TGFβ signaling in adipose tissue, together with up-regulated proliferation and differentiation of adipocyte progenitors. Our findings indicate that CD206+ M2-like macrophages in adipose tissues create a microenvironment that inhibits growth and differentiation of adipocyte progenitors and, thereby, control adiposity and systemic insulin sensitivity.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00231-1

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DOI: 10.1038/s41467-017-00231-1

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