Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

Chao Tian (), Bethann S. Hromatka, Amy K. Kiefer, Nicholas Eriksson, Suzanne M. Noble, Joyce Y. Tung and David A. Hinds ()
Additional contact information
Chao Tian: 23andMe
Bethann S. Hromatka: 23andMe
Amy K. Kiefer: 23andMe
Nicholas Eriksson: 23andMe
Suzanne M. Noble: UCSF
Joyce Y. Tung: 23andMe
David A. Hinds: 23andMe

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P

Date: 2017
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DOI: 10.1038/s41467-017-00257-5

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