Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

Yong-xi Song, Jing-xu Sun, Jun-hua Zhao, Yu-chong Yang, Jin-xin Shi, Zhong-hua Wu, Xiao-wan Chen, Peng Gao, Zhi-feng Miao and Zhen-ning Wang ()
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Yong-xi Song: The First Affiliated Hospital of China Medical University
Jing-xu Sun: The First Affiliated Hospital of China Medical University
Jun-hua Zhao: The First Affiliated Hospital of China Medical University
Yu-chong Yang: The First Affiliated Hospital of China Medical University
Jin-xin Shi: The First Affiliated Hospital of China Medical University
Zhong-hua Wu: The First Affiliated Hospital of China Medical University
Xiao-wan Chen: The First Affiliated Hospital of China Medical University
Peng Gao: The First Affiliated Hospital of China Medical University
Zhi-feng Miao: The First Affiliated Hospital of China Medical University
Zhen-ning Wang: The First Affiliated Hospital of China Medical University

Nature Communications, 2017, vol. 8, issue 1, 1-17

Abstract: Abstract Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.

Date: 2017
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DOI: 10.1038/s41467-017-00304-1

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