The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning

Victor Briz, Leonardo Restivo, Emanuela Pasciuto, Konrad Juczewski, Valentina Mercaldo, Adrian C. Lo, Pieter Baatsen, Natalia V. Gounko, Antonella Borreca, Tiziana Girardi, Rossella Luca, Julie Nys, Rogier B. Poorthuis, Huibert D. Mansvelder, Gilberto Fisone, Martine Ammassari-Teule, Lutgarde Arckens, Patrik Krieger, Rhiannon Meredith and Claudia Bagni ()
Additional contact information
Victor Briz: KU Leuven
Leonardo Restivo: Institute of Cell Biology and Neurobiology, CNR
Emanuela Pasciuto: KU Leuven
Konrad Juczewski: Karolinska Institutet
Valentina Mercaldo: KU Leuven
Adrian C. Lo: KU Leuven
Pieter Baatsen: VIB Electron Microscopy Platform & Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, Department of Neurosciences KU Leuven
Natalia V. Gounko: VIB Electron Microscopy Platform & Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, Department of Neurosciences KU Leuven
Antonella Borreca: KU Leuven
Tiziana Girardi: VIB Center for Brain & Disease Research, Department of Neurosciences KU Leuven
Rossella Luca: KU Leuven
Julie Nys: KU Leuven
Rogier B. Poorthuis: VU University
Huibert D. Mansvelder: VU University
Gilberto Fisone: Karolinska Institutet
Martine Ammassari-Teule: Institute of Cell Biology and Neurobiology, CNR
Lutgarde Arckens: KU Leuven
Patrik Krieger: Karolinska Institutet
Rhiannon Meredith: VU University
Claudia Bagni: KU Leuven

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract The brain cytoplasmic (BC1) RNA is a non-coding RNA (ncRNA) involved in neuronal translational control. Absence of BC1 is associated with altered glutamatergic transmission and maladaptive behavior. Here, we show that pyramidal neurons in the barrel cortex of BC1 knock out (KO) mice display larger excitatory postsynaptic currents and increased spontaneous activity in vivo. Furthermore, BC1 KO mice have enlarged spine heads and postsynaptic densities and increased synaptic levels of glutamate receptors and PSD-95. Of note, BC1 KO mice show aberrant structural plasticity in response to whisker deprivation, impaired texture novel object recognition and altered social behavior. Thus, our study highlights a role for BC1 RNA in experience-dependent plasticity and learning in the mammalian adult neocortex, and provides insight into the function of brain ncRNAs regulating synaptic transmission, plasticity and behavior, with potential relevance in the context of intellectual disabilities and psychiatric disorders.

Date: 2017
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DOI: 10.1038/s41467-017-00311-2

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