Myosin efflux promotes cell elongation to coordinate chromosome segregation with cell cleavage

Emilie Montembault (), Marie-Charlotte Claverie, Lou Bouit, Cedric Landmann, James Jenkins, Anna Tsankova, Clemens Cabernard and Anne Royou ()
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Emilie Montembault: University of Bordeaux, CNRS, UMR5095, Institut Européen de Chimie et Biologie
Marie-Charlotte Claverie: University of Bordeaux, CNRS, UMR5095, Institut Européen de Chimie et Biologie
Lou Bouit: University of Bordeaux, CNRS, UMR5095, Institut Européen de Chimie et Biologie
Cedric Landmann: University of Bordeaux, CNRS, UMR5095, Institut Européen de Chimie et Biologie
James Jenkins: University of Bordeaux, CNRS, UMR5095, Institut Européen de Chimie et Biologie
Anna Tsankova: University of Washington
Clemens Cabernard: University of Washington
Anne Royou: University of Bordeaux, CNRS, UMR5095, Institut Européen de Chimie et Biologie

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Chromatid segregation must be coordinated with cytokinesis to preserve genomic stability. Here we report that cells clear trailing chromatids from the cleavage site by undergoing two phases of cell elongation. The first phase relies on the assembly of a wide contractile ring. The second phase requires the activity of a pool of myosin that flows from the ring and enriches the nascent daughter cell cortices. This myosin efflux is a novel feature of cytokinesis and its duration is coupled to nuclear envelope reassembly and the nuclear sequestration of the Rho-GEF Pebble. Trailing chromatids induce a delay in nuclear envelope reassembly concomitant with prolonged cortical myosin activity, thus providing forces for the second elongation. We propose that the modulation of cortical myosin dynamics is part of the cellular response triggered by a “chromatid separation checkpoint” that delays nuclear envelope reassembly and, consequently, Pebble nuclear sequestration when trailing chromatids are present at the midzone.

Date: 2017
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DOI: 10.1038/s41467-017-00337-6

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