CLEC5A is a critical receptor in innate immunity against Listeria infection

Szu-Ting Chen, Fei-Ju Li, Tzy-yun Hsu, Shu-Mei Liang, Yi-Chen Yeh, Wen-Yu Liao, Teh-Ying Chou, Nien-Jun Chen, Michael Hsiao, Wen-Bin Yang and Shie-Liang Hsieh ()
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Szu-Ting Chen: National Yang-Ming University
Fei-Ju Li: National Yang-Ming University
Tzy-yun Hsu: Academia Sinica
Shu-Mei Liang: Academia Sinica
Yi-Chen Yeh: Taipei Veterans General Hospital
Wen-Yu Liao: Academia Sinica
Teh-Ying Chou: National Yang-Ming University
Nien-Jun Chen: National Yang-Ming University
Michael Hsiao: Academia Sinica
Wen-Bin Yang: Academia Sinica
Shie-Liang Hsieh: National Yang-Ming University

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the Flavivirus family and has critical functions in response to dengue virus and Japanese encephalitis virus. Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to Listeria monocytogenes. Inoculation of Clec5a −/− mice with L. monocytogenes causes rapid bacterial spreading, increased bacterial loads in the blood and liver, and severe liver necrosis. In these mice, IL-1β, IL-17A, and TNF expression is inhibited, CCL2 is induced, and large numbers of CD11b+Ly6ChiCCR2hiCX3CR1low inflammatory monocytes infiltrate the liver. By day 5 of infection, these mice also have fewer IL-17A+ γδ T cells, severe liver necrosis and a higher chance of fatality. Thus, CLEC5A has a pivotal function in the activation of multiple aspects of innate immunity against bacterial invasion.

Date: 2017
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DOI: 10.1038/s41467-017-00356-3

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