Network heterogeneity regulates steering in actin-based motility

Rajaa Boujemaa-Paterski, Cristian Suarez, Tobias Klar, Jie Zhu, Christophe Guérin, Alex Mogilner (), Manuel Théry () and Laurent Blanchoin ()
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Rajaa Boujemaa-Paterski: Université Grenoble-Alpes/CEA/CNRS/INRA
Cristian Suarez: Université Grenoble-Alpes/CEA/CNRS/INRA
Tobias Klar: Université Grenoble-Alpes/CEA/CNRS/INRA
Jie Zhu: New York University
Christophe Guérin: Université Grenoble-Alpes/CEA/CNRS/INRA
Alex Mogilner: New York University
Manuel Théry: Université Grenoble-Alpes/CEA/CNRS/INRA
Laurent Blanchoin: Université Grenoble-Alpes/CEA/CNRS/INRA

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract The growth of branched actin networks powers cell-edge protrusions and motility. A heterogeneous density of actin, which yields to a tunable cellular response, characterizes these dynamic structures. We study how actin organization controls both the rate and the steering during lamellipodium growth. We use a high-resolution surface structuration assay combined with mathematical modeling to describe the growth of a reconstituted lamellipodium. We demonstrate that local monomer depletion at the site of assembly negatively impacts the network growth rate. At the same time, network architecture tunes the protrusion efficiency, and regulates the rate of growth. One consequence of this interdependence between monomer depletion and network architecture effects is the ability of heterogeneous network to impose steering during motility. Therefore, we have established that the general principle, by which the cell can modulate the rate and the direction of a protrusion, is by varying both density and architecture of its actin network.

Date: 2017
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DOI: 10.1038/s41467-017-00455-1

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