APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih- De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang () and Yu-Sun Chang ()
Additional contact information
Ting-Wen Chen: Chang Gung University
Chi-Ching Lee: Chang Gung University
Hsuan Liu: Chang Gung University
Chi-Sheng Wu: Chang Gung University
Curtis R. Pickering: the University of Texas MD Anderson Cancer Center
Po-Jung Huang: Chang Gung University
Jing Wang: the University of Texas MD Anderson Cancer Center
Ian Yi-Feng Chang: Chang Gung University
Yuan-Ming Yeh: Chang Gung University
Chih- De Chen: Chang Gung University
Hsin-Pai Li: Chang Gung University
Ji-Dung Luo: Chang Gung University
Bertrand Chin-Ming Tan: Chang Gung University
Timothy En Haw Chan: Chang Gung University
Chuen Hsueh: Chang Gung University
Lichieh Julie Chu: Chang Gung University
Yi-Ting Chen: Chang Gung University
Bing Zhang: Baylor College of Medicine
Chia-Yu Yang: Chang Gung University
Chih-Ching Wu: Chang Gung University
Chia-Wei Hsu: Chang Gung University
Lai-Chu See: Chang Gung University
Petrus Tang: Chang Gung University
Jau-Song Yu: Chang Gung University
Wei-Chao Liao: Chang Gung University
Wei-Fan Chiang: Chi-Mei Medical Center
Henry Rodriguez: National Cancer Institute, US National Institutes of Health, Bethesda
Jeffrey N. Myers: Chang Gung Memorial Hospital at Linkou
Kai-Ping Chang: Chang Gung Memorial Hospital at Linkou
Yu-Sun Chang: Chang Gung University

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Oral squamous cell carcinoma is a prominent cancer worldwide, particularly in Taiwan. By integrating omics analyses in 50 matched samples, we uncover in Taiwanese patients a predominant mutation signature associated with cytidine deaminase APOBEC, which correlates with the upregulation of APOBEC3A expression in the APOBEC3 gene cluster at 22q13. APOBEC3A expression is significantly higher in tumors carrying APOBEC3B-deletion allele(s). High-level APOBEC3A expression is associated with better overall survival, especially among patients carrying APOBEC3B-deletion alleles, as examined in a second cohort (n = 188; p = 0.004). The frequency of APOBEC3B-deletion alleles is ~50% in 143 genotyped oral squamous cell carcinoma -Taiwan samples (27A3B −/−:89A3B +/−:27A3B +/+), compared to the 5.8% found in 314 OSCC-TCGA samples. We thus report a frequent APOBEC mutational profile, which relates to a APOBEC3B-deletion germline polymorphism in Taiwanese oral squamous cell carcinoma that impacts expression of APOBEC3A, and is shown to be of clinical prognostic relevance. Our finding might be recapitulated by genomic studies in other cancer types.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-017-00493-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00493-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-00493-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().