Macrophage-released ADAMTS1 promotes muscle stem cell activation

Hongqing Du, Chung-Hsuan Shih, Michael N. Wosczyna, Alisa A. Mueller, Joonseok Cho, Abhishek Aggarwal, Thomas A. Rando and Brian J. Feldman ()
Additional contact information
Hongqing Du: Stanford University
Chung-Hsuan Shih: Stanford University
Michael N. Wosczyna: Stanford University
Alisa A. Mueller: Stanford University
Joonseok Cho: Stanford University
Abhishek Aggarwal: Stanford University
Thomas A. Rando: Stanford University
Brian J. Feldman: Stanford University

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Coordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular signals that coordinate this regulation are poorly understood. Here we show that macrophages at sites of muscle injury induce activation of satellite cells via expression of Adamts1. Overexpression of Adamts1 in macrophages in vivo is sufficient to increase satellite cell activation and improve muscle regeneration in young mice. We demonstrate that NOTCH1 is a target of ADAMTS1 metalloproteinase activity, which reduces Notch signaling, leading to increased satellite cell activation. These results identify Adamts1 as a potent extracellular regulator of satellite cell activation and have significant implications for understanding the regulation of satellite cell activity and regeneration after muscle injury.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-017-00522-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00522-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-00522-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().