Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

Zhiyuan Niu, Qian Shi, Wenlong Zhang, Yuxin Shu, Nanfei Yang, Bing Chen, Qingsong Wang, Xuyang Zhao, Jiajia Chen, Nan Cheng, Xiujing Feng, Zichun Hua, Jianguo Ji and Pingping Shen ()
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Zhiyuan Niu: Nanjing University
Qian Shi: The University of Texas Health Science Center at San Antonio
Wenlong Zhang: Nanjing University
Yuxin Shu: Nanjing University
Nanfei Yang: Nanjing University
Bing Chen: the Affiliated Hospital of Nanjing University Medical School
Qingsong Wang: Peking University
Xuyang Zhao: Peking University
Jiajia Chen: Nanjing University
Nan Cheng: Nanjing University
Xiujing Feng: Nanjing University
Zichun Hua: Nanjing University
Jianguo Ji: Peking University
Pingping Shen: Nanjing University

Nature Communications, 2017, vol. 8, issue 1, 1-18

Abstract: Abstract Tumor-associated macrophages are increasingly viewed as a target of great relevance in the tumor microenvironment, because of their important role in cancer progression and metastasis. However, the endogenous regulatory mechanisms underlying tumor-associated macrophage differentiation remain largely unknown. Here, we report that caspase-1 promotes tumor-associated macrophage differentiation by cleaving peroxisome proliferator-activated receptor gamma (PPARγ) at Asp64, thus generating a 41 kDa fragment. This truncated PPARγ translocates to mitochondria, where it directly interacts with medium-chain acyl-CoA dehydrogenase (MCAD). This binding event attenuates MCAD activity and inhibits fatty acid oxidation, thereby leading to the accumulation of lipid droplets and promoting tumor-associated macrophage differentiation. Furthermore, the administration of caspase-1 inhibitors or the infusion of bone marrow-derived macrophages genetically engineered to overexpress murine MCAD markedly suppresses tumor growth. Therefore, targeting the caspase-1/PPARγ/MCAD pathway might be a promising therapeutic approach to prevent tumor progression.

Date: 2017
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DOI: 10.1038/s41467-017-00523-6

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