The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

Jinglin L. Xie, Longguang Qin, Zhengqiang Miao, Ben T. Grys, Jacinto De La Cruz Diaz, Kenneth Ting, Jonathan R. Krieger, Jiefei Tong, Kaeling Tan, Michelle D. Leach, Troy Ketela, Michael F. Moran, Damian J. Krysan, Charles Boone, Brenda J. Andrews, Anna Selmecki, Koon Ho Wong, Nicole Robbins and Leah E. Cowen ()
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Jinglin L. Xie: University of Toronto
Longguang Qin: University of Macau
Zhengqiang Miao: University of Macau
Ben T. Grys: University of Toronto
Jacinto De La Cruz Diaz: University of Rochester
Kenneth Ting: University of Toronto
Jonathan R. Krieger: SPARC Biocentre
Jiefei Tong: Peter Gilgan Centre for Research and Learning
Kaeling Tan: University of Macau
Michelle D. Leach: University of Toronto
Troy Ketela: University of Toronto
Michael F. Moran: University of Toronto
Damian J. Krysan: University of Rochester
Charles Boone: University of Toronto
Brenda J. Andrews: University of Toronto
Anna Selmecki: Creighton University School of Medicine
Koon Ho Wong: University of Macau
Nicole Robbins: University of Toronto
Leah E. Cowen: University of Toronto

Nature Communications, 2017, vol. 8, issue 1, 1-18

Abstract: Abstract The capacity to coordinate environmental sensing with initiation of cellular responses underpins microbial survival and is crucial for virulence and stress responses in microbial pathogens. Here we define circuitry that enables the fungal pathogen Candida albicans to couple cell cycle dynamics with responses to cell wall stress induced by echinocandins, a front-line class of antifungal drugs. We discover that the C. albicans transcription factor Cas5 is crucial for proper cell cycle dynamics and responses to echinocandins, which inhibit β-1,3-glucan synthesis. Cas5 has distinct transcriptional targets under basal and stress conditions, is activated by the phosphatase Glc7, and can regulate the expression of target genes in concert with the transcriptional regulators Swi4 and Swi6. Thus, we illuminate a mechanism of transcriptional control that couples cell wall integrity with cell cycle regulation, and uncover circuitry governing antifungal drug resistance.

Date: 2017
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DOI: 10.1038/s41467-017-00547-y

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