Nanopore extended field-effect transistor for selective single-molecule biosensing

Ren Ren, Yanjun Zhang (), Binoy Paulose Nadappuram, Bernice Akpinar, David Klenerman, Aleksandar P. Ivanov (), Joshua B. Edel () and Yuri Korchev
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Ren Ren: Imperial College London
Yanjun Zhang: Imperial College London
Binoy Paulose Nadappuram: Imperial College London
Bernice Akpinar: Imperial College London
David Klenerman: University of Cambridge
Aleksandar P. Ivanov: Imperial College London
Joshua B. Edel: Imperial College London
Yuri Korchev: Imperial College London

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract There has been a significant drive to deliver nanotechnological solutions to biosensing, yet there remains an unmet need in the development of biosensors that are affordable, integrated, fast, capable of multiplexed detection, and offer high selectivity for trace analyte detection in biological fluids. Herein, some of these challenges are addressed by designing a new class of nanoscale sensors dubbed nanopore extended field-effect transistor (nexFET) that combine the advantages of nanopore single-molecule sensing, field-effect transistors, and recognition chemistry. We report on a polypyrrole functionalized nexFET, with controllable gate voltage that can be used to switch on/off, and slow down single-molecule DNA transport through a nanopore. This strategy enables higher molecular throughput, enhanced signal-to-noise, and even heightened selectivity via functionalization with an embedded receptor. This is shown for selective sensing of an anti-insulin antibody in the presence of its IgG isotype.

Date: 2017
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DOI: 10.1038/s41467-017-00549-w

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