Signalling strength determines proapoptotic functions of STING

Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke and Andrea Ablasser ()
Additional contact information
Muhammet F. Gulen: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Ute Koch: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Simone M. Haag: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Fabian Schuler: Medical University of Innsbruck
Lionel Apetoh: Université de Bourgogne
Andreas Villunger: Medical University of Innsbruck
Freddy Radtke: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Andrea Ablasser: Ecole Polytechnique Fédérale de Lausanne (EPFL)

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS–STING signalling pathway, which initiates a gene expression programme linked to cellular activation and cytokine production. Whether the outcome of the STING response varies between distinct cell types remains largely unknown. Here we show that T cells exhibit an intensified STING response, which leads to the expression of a distinct set of genes and results in the induction of apoptosis. Of note, this proapoptotic STING response is still functional in cancerous T cells and delivery of small molecule STING agonists prevents in vivo growth of T-cell-derived tumours independent of its adjuvant activity. Our results demonstrate how the magnitude of STING signalling can shape distinct effector responses, which may permit for cell type-adjusted behaviours towards endogenous or exogenous insults.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/s41467-017-00573-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00573-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-00573-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().