A V0 core neuronal circuit for inspiration

Jinjin Wu, Paolo Capelli, Julien Bouvier, Martyn Goulding, Silvia Arber and Gilles Fortin ()
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Jinjin Wu: Paris-Saclay Institute of Neuroscience
Paolo Capelli: University of Basel
Julien Bouvier: Paris-Saclay Institute of Neuroscience
Martyn Goulding: Salk Institute for Biological Studies
Silvia Arber: University of Basel
Gilles Fortin: Paris-Saclay Institute of Neuroscience

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Breathing in mammals relies on permanent rhythmic and bilaterally synchronized contractions of inspiratory pump muscles. These motor drives emerge from interactions between critical sets of brainstem neurons whose origins and synaptic ordered organization remain obscure. Here, we show, using a virus-based transsynaptic tracing strategy from the diaphragm muscle in the mouse, that the principal inspiratory premotor neurons share V0 identity with, and are connected by, neurons of the preBötzinger complex that paces inspiration. Deleting the commissural projections of V0s results in left-right desynchronized inspiratory motor commands in reduced brain preparations and breathing at birth. This work reveals the existence of a core inspiratory circuit in which V0 to V0 synapses enabling function of the rhythm generator also direct its output to secure bilaterally coordinated contractions of inspiratory effector muscles required for efficient breathing.

Date: 2017
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DOI: 10.1038/s41467-017-00589-2

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