interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration

Hiroshi Tsujioka, Takekazu Kunieda, Yuki Katou, Katsuhiko Shirahige, Taro Fukazawa () and Takeo Kubo
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Hiroshi Tsujioka: The University of Tokyo
Takekazu Kunieda: The University of Tokyo
Yuki Katou: the University of Tokyo
Katsuhiko Shirahige: the University of Tokyo
Taro Fukazawa: The University of Tokyo
Takeo Kubo: The University of Tokyo

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Unlike mammals, Xenopus laevis tadpoles possess high ability to regenerate their lost organs. In amphibians, the main source of regenerated tissues is lineage-restricted tissue stem cells, but the mechanisms underlying induction, maintenance and differentiation of these stem/progenitor cells in the regenerating organs are poorly understood. We previously reported that interleukin-11 (il-11) is highly expressed in the proliferating cells of regenerating Xenopus tadpole tails. Here, we show that il-11 knockdown (KD) shortens the regenerated tail length, and the phenotype is rescued by forced-il-11-expression in the KD tadpoles. Moreover, marker genes for undifferentiated notochord, muscle, and sensory neurons are downregulated in the KD tadpoles, and the forced-il-11-expression in intact tadpole tails induces expression of these marker genes. Our findings demonstrate that il-11 is necessary for organ regeneration, and suggest that IL-11 plays a key role in the induction and maintenance of undifferentiated progenitors across cell lineages during Xenopus tail regeneration.

Date: 2017
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DOI: 10.1038/s41467-017-00594-5

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