In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging

Janggun Jo, Chang H. Lee, Raoul Kopelman () and Xueding Wang ()
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Janggun Jo: University of Michigan
Chang H. Lee: University of Michigan
Raoul Kopelman: University of Michigan
Xueding Wang: University of Michigan

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Changes of physiological pH are correlated with several pathologies, therefore the development of more effective medical pH imaging methods is of paramount importance. Here, we report on an in vivo pH mapping nanotechnology. This subsurface chemical imaging is based on tumor-targeted, pH sensing nanoprobes and multi-wavelength photoacoustic imaging (PAI). The nanotechnology consists of an optical pH indicator, SNARF-5F, 5-(and-6)-Carboxylic Acid, encapsulated into polyacrylamide nanoparticles with surface modification for tumor targeting. Facilitated by multi-wavelength PAI plus a spectral unmixing technique, the accuracy of pH measurement inside the biological environment is not susceptible to the background optical absorption of biomolecules, i.e., hemoglobins. As a result, both the pH levels and the hemodynamic properties across the entire tumor can be quantitatively evaluated with high sensitivity and high spatial resolution in in vivo cancer models. The imaging technology reported here holds the potential for both research on and clinical management of a variety of cancers.

Date: 2017
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DOI: 10.1038/s41467-017-00598-1

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