Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1

Margit Rosner, Ha Thi Thanh Pham, Richard Moriggl and Markus Hengstschläger ()
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Margit Rosner: Medical University of Vienna
Ha Thi Thanh Pham: Medical University of Vienna
Richard Moriggl: Ludwig Boltzmann Institute for Cancer Research
Markus Hengstschläger: Medical University of Vienna

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract Controlled invasion is essential during many physiological processes, whereas its deregulation is a hallmark of cancer. Here we demonstrate that embryonic, induced pluripotent and amniotic fluid stem cells share the property to induce the invasion of primary somatic cells of various origins through insulin-like growth factor I (IGF-I)- or II (IGF-II)-mediated paracrine activation of mechanistic target of rapamycin complex 1 (mTORC1). We propose a model in which downstream of mTORC1 this stem cell-induced invasion is mediated by hypoxia-inducible factor 1-alpha (HIF-1α)-regulated matrix metalloproteinases. Manipulating the IGF signalling pathway in the context of teratoma formation experiments demonstrates that human stem cells use this mechanism to induce invasion and thereby attract cells from the microenvironment in vivo. In this study we have identified a so far unknown feature of human stem cells, which might play a role for the development of stem cell-derived tumours.

Date: 2017
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DOI: 10.1038/s41467-017-00661-x

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