Transcription factor Foxo1 is essential for IL-9 induction in T helper cells

Sakshi Malik, Srikanth Sadhu, Srikanth Elesela, Ramendra Pati Pandey, Amanpreet Singh Chawla, Deepak Sharma, Lipsa Panda, Deepak Rathore, Balram Ghosh, Vineet Ahuja and Amit Awasthi ()
Additional contact information
Sakshi Malik: Translational Health Science & Technology Institute
Srikanth Sadhu: Translational Health Science & Technology Institute
Srikanth Elesela: Translational Health Science & Technology Institute
Ramendra Pati Pandey: Translational Health Science & Technology Institute
Amanpreet Singh Chawla: National Institute of Immunology
Deepak Sharma: Indian Institute of Technology Roorkee
Lipsa Panda: Institute of Genomics and Integrative Biology (IGIB)
Deepak Rathore: Translational Health Science & Technology Institute
Balram Ghosh: Institute of Genomics and Integrative Biology (IGIB)
Vineet Ahuja: All India Institute of Medical Sciences (AIIMS)
Amit Awasthi: Translational Health Science & Technology Institute

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Interleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial function in allergic inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune responses. In addition to Th9, Th2, Th17 and Foxp3+ regulatory T (Treg) cells produce IL-9. A transcription factor that is critical for IL-9 induction in Th2, Th9 and Th17 cells has not been identified. Here we show that the forkhead family transcription factor Foxo1 is required for IL-9 induction in Th9 and Th17 cells. We further show that inhibition of AKT enhances IL-9 induction in Th9 cells while it reciprocally regulates IL-9 and IL-17 in Th17 cells via Foxo1. Mechanistically, Foxo1 binds and transactivates IL-9 and IRF4 promoters in Th9, Th17 and iTreg cells. Furthermore, loss of Foxo1 attenuates IL-9 in mouse and human Th9 and Th17 cells, and ameliorates allergic inflammation in asthma. Our findings thus identify that Foxo1 is essential for IL-9 induction in Th9 and Th17 cells.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-017-00674-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00674-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-00674-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().