DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1

Jing Ting Wong, Farzanah Akhbar, Amanda Yunn Ee Ng, Mandy Li-Ian Tay, Gladys Jing En Loi and Jun Wei Pek ()
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Jing Ting Wong: Ngee Ann Polytechnic
Farzanah Akhbar: Temasek Polytechnic
Amanda Yunn Ee Ng: 1 Research Link National University of Singapore
Mandy Li-Ian Tay: 1 Research Link National University of Singapore
Gladys Jing En Loi: National University of Singapore
Jun Wei Pek: 1 Research Link National University of Singapore

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Stable intronic sequence RNAs (sisRNAs) are by-products of splicing and regulate gene expression. How sisRNAs are regulated is unclear. Here we report that a double-stranded RNA binding protein, Disco-interacting protein 1 (DIP1) regulates sisRNAs in Drosophila. DIP1 negatively regulates the abundance of sisR-1 and INE-1 sisRNAs. Fine-tuning of sisR-1 by DIP1 is important to maintain female germline stem cell homeostasis by modulating germline stem cell differentiation and niche adhesion. Drosophila DIP1 localizes to a nuclear body (satellite body) and associates with the fourth chromosome, which contains a very high density of INE-1 transposable element sequences that are processed into sisRNAs. DIP1 presumably acts outside the satellite bodies to regulate sisR-1, which is not on the fourth chromosome. Thus, our study identifies DIP1 as a sisRNA regulatory protein that controls germline stem cell self-renewal in Drosophila.

Date: 2017
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DOI: 10.1038/s41467-017-00684-4

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