Tango7 regulates cortical activity of caspases during reaper-triggered changes in tissue elasticity

Yunsik Kang, Sarah D. Neuman and Arash Bashirullah ()
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Yunsik Kang: University of Wisconsin-Madison
Sarah D. Neuman: University of Wisconsin-Madison
Arash Bashirullah: University of Wisconsin-Madison

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Caspases perform critical functions in both living and dying cells; however, how caspases perform physiological functions without killing the cell remains unclear. Here we identify a novel physiological function of caspases at the cortex of Drosophila salivary glands. In living glands, activation of the initiator caspase dronc triggers cortical F-actin dismantling, enabling the glands to stretch as they accumulate secreted products in the lumen. We demonstrate that tango7, not the canonical Apaf-1-adaptor dark, regulates dronc activity at the cortex; in contrast, dark is required for cytoplasmic activity of dronc during salivary gland death. Therefore, tango7 and dark define distinct subcellular domains of caspase activity. Furthermore, tango7-dependent cortical dronc activity is initiated by a sublethal pulse of the inhibitor of apoptosis protein (IAP) antagonist reaper. Our results support a model in which biological outcomes of caspase activation are regulated by differential amplification of IAP antagonists, unique caspase adaptor proteins, and mutually exclusive subcellular domains of caspase activity.

Date: 2017
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DOI: 10.1038/s41467-017-00693-3

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