Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

Qingbo Huang, Yin Sun, Xin Ma, Yu Gao, Xintao Li, Yuanjie Niu, Xu Zhang () and Chawnshang Chang ()
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Qingbo Huang: Chinese PLA General Hospital
Yin Sun: University of Rochester Medical Center
Xin Ma: Chinese PLA General Hospital
Yu Gao: Chinese PLA General Hospital
Xintao Li: Chinese PLA General Hospital
Yuanjie Niu: Tianjin Medical University
Xu Zhang: Chinese PLA General Hospital
Chawnshang Chang: University of Rochester Medical Center

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Abstract Clear cell renal cell carcinoma (ccRCC) is a gender-biased tumor. Here we report that there is also a gender difference between pulmonary metastasis and lymph node metastasis showing that the androgen receptor (AR)-positive ccRCC may prefer to metastasize to lung rather than to lymph nodes. A higher AR expression increases ccRCC hematogenous metastasis yet decreases ccRCC lymphatic metastases. Mechanism dissection indicates that AR enhances miR-185-5p expression via binding to the androgen response elements located on the promoter of miR-185-5p, which suppresses VEGF-C expression via binding to its 3′ UTR. In contrast, AR-enhanced miR-185-5p also promotes HIF2α/VEGF-A expression via binding to the promoter region of HIF2α. Together, these results provide a unique mechanism by which AR can either increase or decrease ccRCC metastasis at different sites and may help us to develop combined therapies using anti-AR and anti-VEGF-C compounds to better suppress ccRCC progression.

Date: 2017
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DOI: 10.1038/s41467-017-00701-6

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