IgG1 memory B cells keep the memory of IgE responses

Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P. Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J. Lafaille and Maria A. Curotto de Lafaille ()
Additional contact information
Jin-Shu He: Singapore Immunology Network (SIgN)
Sharrada Subramaniam: Singapore Immunology Network (SIgN)
Vipin Narang: Singapore Immunology Network (SIgN)
Kandhadayar Srinivasan: Singapore Immunology Network (SIgN)
Sean P. Saunders: New York University School of Medicine
Daniel Carbajo: Singapore Immunology Network (SIgN)
Tsao Wen-Shan: Singapore Immunology Network (SIgN)
Nur Hidayah Hamadee: Singapore Immunology Network (SIgN)
Josephine Lum: Singapore Immunology Network (SIgN)
Andrea Lee: Singapore Immunology Network (SIgN)
Jinmiao Chen: Singapore Immunology Network (SIgN)
Michael Poidinger: Singapore Immunology Network (SIgN)
Francesca Zolezzi: Singapore Immunology Network (SIgN)
Juan J. Lafaille: New York University School of Medicine
Maria A. Curotto de Lafaille: Singapore Immunology Network (SIgN)

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B cells in IgE production and find that two subsets of IgG1 memory B cells, CD80+CD73+ and CD80−CD73−, contribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE. Furthermore, repertoire analysis indicates that high affinity IgE and IgG1 plasma cells differentiate from rare CD80+CD73+ high affinity memory clones without undergoing further mutagenesis. By identifying the cellular origin of high affinity IgE and the clonal selection of high affinity memory B cells into the plasma cell fate, our findings provide fundamental insights into the pathogenesis of allergies, and on the mechanisms of antibody production in memory B cell responses.

Date: 2017
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DOI: 10.1038/s41467-017-00723-0

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