Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents

Julie Seibt (), Clément J. Richard, Johanna Sigl-Glöckner, Naoya Takahashi, David I. Kaplan, Guy Doron, Denis Limoges, Christina Bocklisch and Matthew E. Larkum ()
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Julie Seibt: Charité-Universitätsmedizin
Clément J. Richard: Charité-Universitätsmedizin
Johanna Sigl-Glöckner: Humboldt-Universitätzu Berlin
Naoya Takahashi: Humboldt-Universität zu Berlin
David I. Kaplan: Charité-Universitätsmedizin
Guy Doron: Humboldt-Universität zu Berlin
Denis Limoges: Universität Bern
Christina Bocklisch: Humboldt-Universität zu Berlin
Matthew E. Larkum: Humboldt-Universität zu Berlin

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep. Here, we report that calcium activity in populations of neocortical dendrites is increased and synchronised during oscillations in the spindle range in naturally sleeping rodents. Remarkably, the same relationship is not found in cell bodies of the same neurons and throughout the cortical column. Spindles during sleep have been suggested to be important for brain development and plasticity. Our results provide evidence for a physiological link of spindles in the cortex specific to dendrites, the main site of synaptic plasticity.

Date: 2017
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DOI: 10.1038/s41467-017-00735-w

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