Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children

Kuan-Ying Arthur Huang (), Mei-Feng Chen, Yhu-Chering Huang, Shin-Ru Shih, Cheng-Hsun Chiu, Jainn-Jim Lin, Jen-Ren Wang, Kuo-Chien Tsao and Tzou-Yien Lin ()
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Kuan-Ying Arthur Huang: Chang Gung Memorial Hospital
Mei-Feng Chen: Research Center for Emerging Viral Infections, Chang Gung University
Yhu-Chering Huang: Chang Gung Memorial Hospital
Shin-Ru Shih: Research Center for Emerging Viral Infections, Chang Gung University
Cheng-Hsun Chiu: Chang Gung Memorial Hospital
Jainn-Jim Lin: Chang Gung Memorial Hospital
Jen-Ren Wang: College of Medicine, National Cheng Kung University
Kuo-Chien Tsao: Chang Gung Memorial Hospital
Tzou-Yien Lin: Chang Gung Memorial Hospital

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Protective antibody levels are critical for protection from severe enterovirus 71 infection. However, little is known about the specificities and functional properties of the enterovirus 71-specific antibodies induced by natural infection in humans. Here we characterize 191 plasmablast-derived monoclonal antibodies from three enterovirus 71-infected children, each of whom shows a distinct serological response. Of the 84 enterovirus 71-specific antibodies, neutralizing antibodies that target the rims and floor of the capsid canyon exhibit broad and potent activities at the nanogram level against viruses isolated in 1998–2016. We also find a subset of infected children whose enterovirus 71-specific antibodies are focused on the 3- and 2-fold plateau epitopes localized at the margin of pentamers, and this type of antibody response is associated with lower serum titers against recently circulating strains. Our data provide new insights into the enterovirus 71-specific antibodies induced by natural infection at the serological and clonal levels.

Date: 2017
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DOI: 10.1038/s41467-017-00736-9

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