Noise reduction as an emergent property of single-cell aging

Ping Liu, Ruijie Song, Gregory L. Elison, Weilin Peng and Murat Acar ()
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Ping Liu: Yale University
Ruijie Song: Yale University
Gregory L. Elison: Yale University
Weilin Peng: Yale University
Murat Acar: Yale University

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Noise-induced heterogeneity in gene expression is an inherent reality for cells. However, it is not well understood how noise strength changes for a single gene while the host cell is aging. Using a state-of-the-art microfluidic platform, we measure noise dynamics in aging yeast cells by tracking the generation-specific activity of the canonical GAL1 promoter. We observe noise reduction during normal aging of a cell, followed by a short catastrophe phase in which noise increased. We hypothesize that aging-associated increases in chromatin state transitions are behind the observed noise reduction and a stochastic model provides quantitative support to the proposed mechanism. Noise trends measured from strains with altered GAL1 promoter dynamics (constitutively active, synthetic with nucleosome-disfavoring sequences, and in the absence of RPD3, a global remodeling regulator) lend further support to our hypothesis. Observing similar noise dynamics from a different promoter (HHF2) provides support to the generality of our findings.

Date: 2017
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DOI: 10.1038/s41467-017-00752-9

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