Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb

Daniel T. Case, Shawn D. Burton, Jeremy Y. Gedeon, Sean-Paul G. Williams, Nathaniel N. Urban and Rebecca P. Seal ()
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Daniel T. Case: University of Pittsburgh School of Medicine
Shawn D. Burton: Center for the Neural Basis of Cognition
Jeremy Y. Gedeon: University of Pittsburgh School of Medicine
Sean-Paul G. Williams: University of Pittsburgh School of Medicine
Nathaniel N. Urban: University of Pittsburgh School of Medicine
Rebecca P. Seal: University of Pittsburgh School of Medicine

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Cholinergic neurons in the basal forebrain project heavily to the main olfactory bulb, the first processing station in the olfactory pathway. The projections innervate multiple layers of the main olfactory bulb and strongly influence odor discrimination, detection, and learning. The precise underlying circuitry of this cholinergic input to the main olfactory bulb remains unclear, however. Here, we identify a specific basal forebrain cholinergic projection that innervates select neurons concentrated in the internal plexiform layer of the main olfactory bulb. Optogenetic activation of this projection elicits monosynaptic nicotinic and GABAergic currents in glomerular layer-projecting interneurons. Additionally, we show that the projection co-expresses markers for GABAergic neurotransmission. The data thus implicate neurotransmitter co-transmission in the basal forebrain regulation of this inhibitory olfactory microcircuit.

Date: 2017
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DOI: 10.1038/s41467-017-00765-4

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