Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I

Warif Yakoubi, Eulalie Buffin, Damien Cladière, Yulia Gryaznova, Inés Berenguer, Sandra A. Touati, Rocío Gómez, José A. Suja, Jan M. Deursen and Katja Wassmann ()
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Warif Yakoubi: Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS)
Eulalie Buffin: Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS)
Damien Cladière: Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS)
Yulia Gryaznova: Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS)
Inés Berenguer: Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS)
Sandra A. Touati: Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS)
Rocío Gómez: Universidad Autónoma de Madrid
José A. Suja: Universidad Autónoma de Madrid
Jan M. Deursen: Mayo Clinic College of Medicine
Katja Wassmann: Sorbonne Universités, UPMC Univ. Paris 06, Institut de Biologie Paris Seine (IBPS)

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and then from the centromere region in meiosis II. Centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage, in order to maintain sister chromatids together until their separation in meiosis II. Failures in step-wise cohesin removal result in aneuploid gametes, preventing the generation of healthy embryos. Here, we report that kinase activities of Bub1 and Mps1 are required for Sgo2 localisation to the centromere region. Mps1 inhibitor-treated oocytes are defective in centromeric cohesin protection, whereas oocytes devoid of Bub1 kinase activity, which cannot phosphorylate H2A at T121, are not perturbed in cohesin protection as long as Mps1 is functional. Mps1 and Bub1 kinase activities localise Sgo2 in meiosis I preferentially to the centromere and pericentromere respectively, indicating that Sgo2 at the centromere is required for protection.

Date: 2017
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DOI: 10.1038/s41467-017-00774-3

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