Interconnected subsets of memory follicular helper T cells have different effector functions

Assia Asrir, Meryem Aloulou, Mylène Gador, Corine Pérals and Nicolas Fazilleau ()
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Assia Asrir: Centre de Physiopathologie de Toulouse Purpan
Meryem Aloulou: Centre de Physiopathologie de Toulouse Purpan
Mylène Gador: Centre de Physiopathologie de Toulouse Purpan
Corine Pérals: Centre de Physiopathologie de Toulouse Purpan
Nicolas Fazilleau: Centre de Physiopathologie de Toulouse Purpan

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Follicular helper T cells regulate high-affinity antibody production. Memory follicular helper T cells can be local in draining lymphoid organs and circulate in the blood, but the underlying mechanisms of this subdivision are unresolved. Here we show that both memory follicular helper T subsets sustain B-cell responses after reactivation. Local cells promote more plasma cell differentiation, whereas circulating cells promote more secondary germinal centers. In parallel, local memory B cells are homogeneous and programmed to become plasma cells, whereas circulating memory B cells are able to rediversify. Local memory follicular helper T cells have higher affinity T-cell receptors, which correlates with expression of peptide MHC-II at the surface of local memory B cells only. Blocking T-cell receptor–peptide MHC-II interactions induces the release of local memory follicular helper T cells in the circulating compartment. Our studies show that memory follicular helper T localization is highly intertwined with memory B cells, a finding that has important implications for vaccine design.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00843-7

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DOI: 10.1038/s41467-017-00843-7

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