Motionless volumetric photoacoustic microscopy with spatially invariant resolution

Jiamiao Yang, Lei Gong, Xiao Xu, Pengfei Hai, Yuecheng Shen, Yuta Suzuki and Lihong V. Wang ()
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Jiamiao Yang: California Institute of Technology
Lei Gong: Washington University in St Louis
Xiao Xu: Washington University in St Louis
Pengfei Hai: California Institute of Technology
Yuecheng Shen: California Institute of Technology
Yuta Suzuki: Washington University in St Louis
Lihong V. Wang: California Institute of Technology

Nature Communications, 2017, vol. 8, issue 1, 1-7

Abstract: Abstract Photoacoustic microscopy (PAM) is uniquely positioned for biomedical applications because of its ability to visualize optical absorption contrast in vivo in three dimensions. Here we propose motionless volumetric spatially invariant resolution photoacoustic microscopy (SIR-PAM). To realize motionless volumetric imaging, SIR-PAM combines two-dimensional Fourier-spectrum optical excitation with single-element depth-resolved photoacoustic detection. To achieve spatially invariant lateral resolution, propagation-invariant sinusoidal fringes are generated by a digital micromirror device. Further, SIR-PAM achieves 1.5 times finer lateral resolution than conventional PAM. The superior performance was demonstrated in imaging both inanimate objects and animals in vivo with a resolution-invariant axial range of 1.8 mm, 33 times the depth of field of the conventional PAM counterpart. Our work opens new perspectives for PAM in biomedical sciences.

Date: 2017
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DOI: 10.1038/s41467-017-00856-2

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