A long-range cis-regulatory element for class I odorant receptor genes

Tetsuo Iwata, Yoshihito Niimura, Chizuru Kobayashi, Daichi Shirakawa, Hikoyu Suzuki, Takayuki Enomoto, Kazushige Touhara, Yoshihiro Yoshihara and Junji Hirota ()
Additional contact information
Tetsuo Iwata: Tokyo Institute of Technology
Yoshihito Niimura: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Chizuru Kobayashi: Graduate School of Life Science and Technology, Tokyo Institute of Technology
Daichi Shirakawa: Graduate School of Life Science and Technology, Tokyo Institute of Technology
Hikoyu Suzuki: Nihon BioData Corporation
Takayuki Enomoto: Tokyo Institute of Technology
Kazushige Touhara: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Yoshihiro Yoshihara: The University of Tokyo
Junji Hirota: Tokyo Institute of Technology

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that is conserved through mammalian species from the platypus to humans. The J element regulates most class I genes expression by exerting an effect over ~ 3 megabases within the whole cluster. Deletion of the trans J element increases the expression frequencies of class I genes from the intact J allele, indicating that the allelic exclusion of class I genes depends on the activity of the J element. Our data reveal a long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-017-00870-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00870-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-017-00870-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().