The gut microbiome in atherosclerotic cardiovascular disease

Zhuye Jie, Huihua Xia, Shi-Long Zhong, Qiang Feng, Shenghui Li, Suisha Liang, Huanzi Zhong, Zhipeng Liu, Yuan Gao, Hui Zhao, Dongya Zhang, Zheng Su, Zhiwei Fang, Zhou Lan, Junhua Li, Liang Xiao, Jun Li, Ruijun Li, Xiaoping Li, Fei Li, Huahui Ren, Yan Huang, Yangqing Peng, Guanglei Li, Bo Wen, Bo Dong, Ji-Yan Chen, Qing-Shan Geng, Zhi-Wei Zhang, Huanming Yang, Jian Wang, Jun Wang, Xuan Zhang, Lise Madsen, Susanne Brix, Guang Ning, Xun Xu, Xin Liu, Yong Hou, Huijue Jia (), Kunlun He () and Karsten Kristiansen ()
Additional contact information
Zhuye Jie: BGI-Shenzhen
Huihua Xia: BGI-Shenzhen
Shi-Long Zhong: Guangdong Cardiovascular Institute
Qiang Feng: BGI-Shenzhen
Shenghui Li: BGI-Shenzhen
Suisha Liang: BGI-Shenzhen
Huanzi Zhong: BGI-Shenzhen
Zhipeng Liu: BGI-Shenzhen
Yuan Gao: BGI-Shenzhen
Hui Zhao: BGI-Shenzhen
Dongya Zhang: BGI-Shenzhen
Zheng Su: BGI-Shenzhen
Zhiwei Fang: BGI-Shenzhen
Zhou Lan: BGI-Shenzhen
Junhua Li: BGI-Shenzhen
Liang Xiao: BGI-Shenzhen
Jun Li: BGI-Shenzhen
Ruijun Li: Chinese PLA General Hospital
Xiaoping Li: BGI-Shenzhen
Fei Li: BGI-Shenzhen
Huahui Ren: BGI-Shenzhen
Yan Huang: BGI-Shenzhen
Yangqing Peng: BGI-Shenzhen
Guanglei Li: BGI-Shenzhen
Bo Wen: BGI-Shenzhen
Bo Dong: BGI-Shenzhen
Ji-Yan Chen: Guangdong Cardiovascular Institute
Qing-Shan Geng: Guangdong Cardiovascular Institute
Zhi-Wei Zhang: Guangdong Cardiovascular Institute
Huanming Yang: BGI-Shenzhen
Jian Wang: BGI-Shenzhen
Jun Wang: BGI-Shenzhen
Xuan Zhang: Chinese Academy of Medical Sciences and Peking Union Medical College
Lise Madsen: BGI-Shenzhen
Susanne Brix: Technical University of Denmark (DTU)
Guang Ning: Shanghai Jiao Tong University School of Medicine
Xun Xu: BGI-Shenzhen
Xin Liu: BGI-Shenzhen
Yong Hou: BGI-Shenzhen
Huijue Jia: BGI-Shenzhen
Kunlun He: Chinese PLA General Hospital
Karsten Kristiansen: BGI-Shenzhen

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00900-1

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DOI: 10.1038/s41467-017-00900-1

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