Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota () and K. Kataoka ()
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Y. Anraku: The University of Tokyo
H. Kuwahara: Tokyo Medical and Dental University (TMDU)
Y. Fukusato: The University of Tokyo
A. Mizoguchi: The University of Tokyo
T. Ishii: The University of Tokyo
K. Nitta: Tokyo Medical and Dental University (TMDU)
Y. Matsumoto: The University of Tokyo
K. Toh: Kawasaki Institute of Industrial Promotion
K. Miyata: The University of Tokyo
S. Uchida: The University of Tokyo
K. Nishina: Tokyo Medical and Dental University (TMDU)
K. Osada: The University of Tokyo
K. Itaka: The University of Tokyo
N. Nishiyama: Tokyo Institute of Technology
H. Mizusawa: Tokyo Medical and Dental University (TMDU)
T. Yamasoba: The University of Tokyo
T. Yokota: Tokyo Medical and Dental University (TMDU)
K. Kataoka: Kawasaki Institute of Industrial Promotion

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons.

Date: 2017
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DOI: 10.1038/s41467-017-00952-3

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