Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons

Gerardo Rojas-Piloni, Jason M. Guest, Robert Egger, Andrew S. Johnson, Bert Sakmann and Marcel Oberlaender ()
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Gerardo Rojas-Piloni: Max Planck Florida Institute of Neuroscience
Jason M. Guest: Max Planck Florida Institute of Neuroscience
Robert Egger: Max Planck Institute for Biological Cybernetics
Andrew S. Johnson: Max Planck Florida Institute of Neuroscience
Bert Sakmann: Max Planck Florida Institute of Neuroscience
Marcel Oberlaender: Max Planck Florida Institute of Neuroscience

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Pyramidal tract neurons (PTs) represent the major output cell type of the neocortex. To investigate principles of how the results of cortical processing are broadcasted to different downstream targets thus requires experimental approaches, which provide access to the in vivo electrophysiology of PTs, whose subcortical target regions are identified. On the example of rat barrel cortex (vS1), we illustrate that retrograde tracer injections into multiple subcortical structures allow identifying the long-range axonal targets of individual in vivo recorded PTs. Here we report that soma depth and dendritic path lengths within each cortical layer of vS1, as well as spiking patterns during both periods of ongoing activity and during sensory stimulation, reflect the respective subcortical target regions of PTs. We show that these cellular properties result in a structure–function parameter space that allows predicting a PT’s subcortical target region, without the need to inject multiple retrograde tracers.

Date: 2017
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DOI: 10.1038/s41467-017-00971-0

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