Ets transcription factor GABP controls T cell homeostasis and immunity

Chong T. Luo, Hatice U. Osmanbeyoglu, Mytrang H. Do, Michael R. Bivona, Ahmed Toure, Davina Kang, Yuchen Xie, Christina S. Leslie and Ming O. Li ()
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Chong T. Luo: Memorial Sloan Kettering Cancer Center
Hatice U. Osmanbeyoglu: Memorial Sloan Kettering Cancer Center
Mytrang H. Do: Memorial Sloan Kettering Cancer Center
Michael R. Bivona: Memorial Sloan Kettering Cancer Center
Ahmed Toure: Memorial Sloan Kettering Cancer Center
Davina Kang: Memorial Sloan Kettering Cancer Center
Yuchen Xie: Memorial Sloan Kettering Cancer Center
Christina S. Leslie: Memorial Sloan Kettering Cancer Center
Ming O. Li: Memorial Sloan Kettering Cancer Center

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.

Date: 2017
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DOI: 10.1038/s41467-017-01020-6

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