Ecogenomics of virophages and their giant virus hosts assessed through time series metagenomics

Simon Roux, Leong-Keat Chan, Rob Egan, Rex R. Malmstrom, Katherine D. McMahon and Matthew B. Sullivan ()
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Simon Roux: The Ohio State University
Leong-Keat Chan: Department of Energy Joint Genome Institute
Rob Egan: Department of Energy Joint Genome Institute
Rex R. Malmstrom: Department of Energy Joint Genome Institute
Katherine D. McMahon: University of Wisconsin-Madison
Matthew B. Sullivan: The Ohio State University

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Virophages are small viruses that co-infect eukaryotic cells alongside giant viruses (Mimiviridae) and hijack their machinery to replicate. While two types of virophages have been isolated, their genomic diversity and ecology remain largely unknown. Here we use time series metagenomics to identify and study the dynamics of 25 uncultivated virophage populations, 17 of which represented by complete or near-complete genomes, in two North American freshwater lakes. Taxonomic analysis suggests that these freshwater virophages represent at least three new candidate genera. Ecologically, virophage populations are repeatedly detected over years and evolutionary stable, yet their distinct abundance profiles and gene content suggest that virophage genera occupy different ecological niches. Co-occurrence analyses reveal 11 virophages strongly associated with uncultivated Mimiviridae, and three associated with eukaryotes among the Dinophyceae, Rhizaria, Alveolata, and Cryptophyceae groups. Together, these findings significantly augment virophage databases, help refine virophage taxonomy, and establish baseline ecological hypotheses and tools to study virophages in nature.

Date: 2017
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DOI: 10.1038/s41467-017-01086-2

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