Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV

Ann-Muriel Steff (), James Monroe, Kristian Friedrich, Sumana Chandramouli, Thi Lien-Anh Nguyen, Sai Tian, Sarah Vandepaer, Jean-François Toussaint and Andrea Carfi ()
Additional contact information
Ann-Muriel Steff: GSK Vaccines
James Monroe: GSK Vaccines
Kristian Friedrich: GSK Vaccines
Sumana Chandramouli: GSK Vaccines
Thi Lien-Anh Nguyen: GSK Vaccines
Sai Tian: GSK Vaccines
Sarah Vandepaer: Keyrus Biopharma
Jean-François Toussaint: GSK Vaccines
Andrea Carfi: GSK Vaccines

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Human respiratory syncytial virus (hRSV) is responsible for serious lower respiratory tract disease in infants and in older adults, and remains an important vaccine need. RSV fusion (F) glycoprotein is a key target for neutralizing antibodies. RSV F stabilized in its pre-fusion conformation (DS-Cav1 F) induces high neutralizing antibody titers in naïve animals, but it remains unknown to what extent pre-fusion F can boost pre-existing neutralizing responses in RSV seropositive adults. We here assess DS-Cav1 F immunogenicity in seropositive cattle pre-exposed to bovine RSV, a virus closely related to hRSV. A single immunization with non-adjuvanted DS-Cav1 F strongly boosts RSV neutralizing responses, directed towards pre-fusion F-specific epitopes, whereas a post-fusion F is unable to do so. Vaccination with pre-fusion F thus represents a promising strategy for maternal immunization and for other RSV vaccine target populations such as older adults.

Date: 2017
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DOI: 10.1038/s41467-017-01092-4

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