Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton and Erkki Ruoslahti ()
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Aman P. Mann: Sanford Burnham Prebys Medical Discovery Institute
Pablo Scodeller: Sanford Burnham Prebys Medical Discovery Institute
Sazid Hussain: Sanford Burnham Prebys Medical Discovery Institute
Gary B. Braun: Sanford Burnham Prebys Medical Discovery Institute
Tarmo Mölder: University of Tartu
Kadri Toome: University of Tartu
Rajesh Ambasudhan: Scintillon Institute
Tambet Teesalu: University of Tartu
Stuart A. Lipton: Scintillon Institute
Erkki Ruoslahti: Sanford Burnham Prebys Medical Discovery Institute

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Cerebrovascular changes occur in Alzheimer’s disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus of hAPP-J20 mice at different ages. Intravenously injected DAG peptide homes to neurovascular unit endothelial cells and to reactive astrocytes in mouse models of AD. We identified connective tissue growth factor (CTGF), a matricellular protein that is highly expressed in the brain of individuals with AD and in mouse models, as the target of the DAG peptide. We also showed that exogenously delivered DAG homes to the brain in mouse models of glioblastoma, traumatic brain injury, and Parkinson’s disease. DAG may potentially be used as a tool to enhance delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation.

Date: 2017
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DOI: 10.1038/s41467-017-01096-0

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