Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

Musarrat Maisha Reza, Nathiya Subramaniyam, Chu Ming Sim, Xiaojia Ge, Durgalakshmi Sathiakumar, Craig McFarlane, Mridula Sharma and Ravi Kambadur ()
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Musarrat Maisha Reza: Nanyang Technological University
Nathiya Subramaniyam: Brenner Centre for Molecular Medicine
Chu Ming Sim: Brenner Centre for Molecular Medicine
Xiaojia Ge: Brenner Centre for Molecular Medicine
Durgalakshmi Sathiakumar: Brenner Centre for Molecular Medicine
Craig McFarlane: Brenner Centre for Molecular Medicine
Mridula Sharma: National University of Singapore
Ravi Kambadur: Nanyang Technological University

Nature Communications, 2017, vol. 8, issue 1, 1-17

Abstract: Abstract Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic differentiation and myoblast fusion via activation of IL6 signaling. Injection of irisin in mice induces significant hypertrophy and enhances grip strength of uninjured muscle. Following skeletal muscle injury, irisin injection improves regeneration and induces hypertrophy. The effects of irisin on hypertrophy are due to activation of satellite cells and enhanced protein synthesis. In addition, irisin injection rescues loss of skeletal muscle mass following denervation by enhancing satellite cell activation and reducing protein degradation. These data suggest that irisin functions as a pro-myogenic factor in mice.

Date: 2017
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DOI: 10.1038/s41467-017-01131-0

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